The Bioinformatics Competence Center (BICC) contributed to research led by Can Aztekin’s group (now at the Friedrich Miescher Laboratory of the Max Planck Society), which developed a 3D organoid model derived from mouse embryonic stem cells, termed budoids. This model contains AER‑like, surface ectoderm, and mesodermal cell types and recapitulates key features of early limb morphogenesis.
Using this 3D stem cell-derived budoid system, the study shows that AER‑like cells simultaneously influence nearby mesodermal cell fates and promote long‑range tissue organization, enabling cartilage formation and providing a powerful platform to study epithelial signaling-mesoderm interactions. The BICC staff contributed advanced bioinformatics and statistical expertise to the analysis of multiple single‑cell RNA‑seq datasets examined in this paper.
For more information, please see the news release.
Date : 2025-12-03
News source : EPFL.CH
Auteur :
Evangelia Skoufa, Jixing Zhong, Kelly Hu, Oliver Kahre, Georgios Tsissios, Louise Carrau, Antonio Herrera, Albert Dominguez Mantes, Marion Leleu, Alejandro Castilla-Ibeas, Hwanseok Jang, Martin Weigert, Gioele La Manno, Matthias Lutolf, Marian Ros, Can Aztekin. Specialized signaling centers direct cell fate and spatial organization in a mesodermal organoid model. Science Advances 28 November 2025. DOI: 10.1126/sciadv.ady7682.